高流量鼻腔插管（HFNC）为批判性儿童提供了非侵入性呼吸支持，这些儿童可能比其他非侵入性（NIV）技术更容易耐受。及时预测HFNC故障可以提供增加呼吸支持的指示。这项工作开发并比较了机器学习模型来预测HFNC故障。从2010年1月到2月20日至2月的患者EMR进行了患者EMR进行了回顾性研究。培训了长期内记忆（LSTM）模型，以产生连续预测HFNC故障。在HFNC启动后的各个时间使用接收器操作曲线（AUROC）下的区域评估性能。还评估了HFNC启动后2小时后预测的敏感性，特异性，正面和消极预测值（PPV，NPV）。这些指标也以主要呼吸诊断的群组计算。 834 HFNC试验[455培训，173次验证，206检验]符合纳入标准，其中175 [103,30,42]（21.0％）升级至NIV或插管。具有转移学习的LSTM模型通常比LR模型更好地执行，最佳LSTM模型在启动后2小时实现0.78，VS 0.66的AUTOC。使用EMR数据培训的机器学习模型能够在发起24小时内识别出现在HFNC中失败的风险的风险。 LSTM模型结合了转移学习，输入数据持久性和合奏显示的性能提高了LR和标准LSTM模型。

By optimizing the rate-distortion-realism trade-off, generative compression approaches produce detailed, realistic images, even at low bit rates, instead of the blurry reconstructions produced by rate-distortion optimized models. However, previous methods do not explicitly control how much detail is synthesized, which results in a common criticism of these methods: users might be worried that a misleading reconstruction far from the input image is generated. In this work, we alleviate these concerns by training a decoder that can bridge the two regimes and navigate the distortion-realism trade-off. From a single compressed representation, the receiver can decide to either reconstruct a low mean squared error reconstruction that is close to the input, a realistic reconstruction with high perceptual quality, or anything in between. With our method, we set a new state-of-the-art in distortion-realism, pushing the frontier of achievable distortion-realism pairs, i.e., our method achieves better distortions at high realism and better realism at low distortion than ever before.

Data deprivation, or the lack of easily available and actionable information on the well-being of individuals, is a significant challenge for the developing world and an impediment to the design and operationalization of policies intended to alleviate poverty. In this paper we explore the suitability of data derived from OpenStreetMap to proxy for the location of two crucial public services: schools and health clinics. Thanks to the efforts of thousands of digital humanitarians, online mapping repositories such as OpenStreetMap contain millions of records on buildings and other structures, delineating both their location and often their use. Unfortunately much of this data is locked in complex, unstructured text rendering it seemingly unsuitable for classifying schools or clinics. We apply a scalable, unsupervised learning method to unlabeled OpenStreetMap building data to extract the location of schools and health clinics in ten countries in Africa. We find the topic modeling approach greatly improves performance versus reliance on structured keys alone. We validate our results by comparing schools and clinics identified by our OSM method versus those identified by the WHO, and describe OSM coverage gaps more broadly.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Since early in the coronavirus disease 2019 (COVID-19) pandemic, there has been interest in using artificial intelligence methods to predict COVID-19 infection status based on vocal audio signals, for example cough recordings. However, existing studies have limitations in terms of data collection and of the assessment of the performances of the proposed predictive models. This paper rigorously assesses state-of-the-art machine learning techniques used to predict COVID-19 infection status based on vocal audio signals, using a dataset collected by the UK Health Security Agency. This dataset includes acoustic recordings and extensive study participant meta-data. We provide guidelines on testing the performance of methods to classify COVID-19 infection status based on acoustic features and we discuss how these can be extended more generally to the development and assessment of predictive methods based on public health datasets.

The UK COVID-19 Vocal Audio Dataset is designed for the training and evaluation of machine learning models that classify SARS-CoV-2 infection status or associated respiratory symptoms using vocal audio. The UK Health Security Agency recruited voluntary participants through the national Test and Trace programme and the REACT-1 survey in England from March 2021 to March 2022, during dominant transmission of the Alpha and Delta SARS-CoV-2 variants and some Omicron variant sublineages. Audio recordings of volitional coughs, exhalations, and speech were collected in the 'Speak up to help beat coronavirus' digital survey alongside demographic, self-reported symptom and respiratory condition data, and linked to SARS-CoV-2 test results. The UK COVID-19 Vocal Audio Dataset represents the largest collection of SARS-CoV-2 PCR-referenced audio recordings to date. PCR results were linked to 70,794 of 72,999 participants and 24,155 of 25,776 positive cases. Respiratory symptoms were reported by 45.62% of participants. This dataset has additional potential uses for bioacoustics research, with 11.30% participants reporting asthma, and 27.20% with linked influenza PCR test results.

Objective: We aim to develop an open-source natural language processing (NLP) package, SODA (i.e., SOcial DeterminAnts), with pre-trained transformer models to extract social determinants of health (SDoH) for cancer patients, examine the generalizability of SODA to a new disease domain (i.e., opioid use), and evaluate the extraction rate of SDoH using cancer populations. Methods: We identified SDoH categories and attributes and developed an SDoH corpus using clinical notes from a general cancer cohort. We compared four transformer-based NLP models to extract SDoH, examined the generalizability of NLP models to a cohort of patients prescribed with opioids, and explored customization strategies to improve performance. We applied the best NLP model to extract 19 categories of SDoH from the breast (n=7,971), lung (n=11,804), and colorectal cancer (n=6,240) cohorts. Results and Conclusion: We developed a corpus of 629 cancer patients notes with annotations of 13,193 SDoH concepts/attributes from 19 categories of SDoH. The Bidirectional Encoder Representations from Transformers (BERT) model achieved the best strict/lenient F1 scores of 0.9216 and 0.9441 for SDoH concept extraction, 0.9617 and 0.9626 for linking attributes to SDoH concepts. Fine-tuning the NLP models using new annotations from opioid use patients improved the strict/lenient F1 scores from 0.8172/0.8502 to 0.8312/0.8679. The extraction rates among 19 categories of SDoH varied greatly, where 10 SDoH could be extracted from >70% of cancer patients, but 9 SDoH had a low extraction rate (<70% of cancer patients). The SODA package with pre-trained transformer models is publicly available at https://github.com/uf-hobiinformatics-lab/SDoH_SODA.

To date, the best-performing blind super-resolution (SR) techniques follow one of two paradigms: A) generate and train a standard SR network on synthetic low-resolution - high-resolution (LR - HR) pairs or B) attempt to predict the degradations an LR image has suffered and use these to inform a customised SR network. Despite significant progress, subscribers to the former miss out on useful degradation information that could be used to improve the SR process. On the other hand, followers of the latter rely on weaker SR networks, which are significantly outperformed by the latest architectural advancements. In this work, we present a framework for combining any blind SR prediction mechanism with any deep SR network, using a metadata insertion block to insert prediction vectors into SR network feature maps. Through comprehensive testing, we prove that state-of-the-art contrastive and iterative prediction schemes can be successfully combined with high-performance SR networks such as RCAN and HAN within our framework. We show that our hybrid models consistently achieve stronger SR performance than both their non-blind and blind counterparts. Furthermore, we demonstrate our framework's robustness by predicting degradations and super-resolving images from a complex pipeline of blurring, noise and compression.

Bilevel programming has recently received attention in the literature, due to a wide range of applications, including reinforcement learning and hyper-parameter optimization. However, it is widely assumed that the underlying bilevel optimization problem is solved either by a single machine or in the case of multiple machines connected in a star-shaped network, i.e., federated learning setting. The latter approach suffers from a high communication cost on the central node (e.g., parameter server) and exhibits privacy vulnerabilities. Hence, it is of interest to develop methods that solve bilevel optimization problems in a communication-efficient decentralized manner. To that end, this paper introduces a penalty function based decentralized algorithm with theoretical guarantees for this class of optimization problems. Specifically, a distributed alternating gradient-type algorithm for solving consensus bilevel programming over a decentralized network is developed. A key feature of the proposed algorithm is to estimate the hyper-gradient of the penalty function via decentralized computation of matrix-vector products and few vector communications, which is then integrated within our alternating algorithm to give the finite-time convergence analysis under different convexity assumptions. Owing to the generality of this complexity analysis, our result yields convergence rates for a wide variety of consensus problems including minimax and compositional optimization. Empirical results on both synthetic and real datasets demonstrate that the proposed method works well in practice.

图像分类的深卷卷神经网络（CNN）依次交替交替进行卷积和下采样操作，例如合并层或陷入困境的卷积，从而导致较低的分辨率特征网络越深。这些降采样操作节省了计算资源，并在下一层提供了一些翻译不变性以及更大的接收领域。但是，这样做的固有副作用是，在网络深端产生的高级特征始终以低分辨率特征图捕获。逆也是如此，因为浅层总是包含小规模的特征。在生物医学图像分析中，工程师通常负责对仅包含有限信息的非常小的图像贴片进行分类。从本质上讲，这些补丁甚至可能不包含对象，而分类取决于图像纹理中未知量表的微妙基础模式的检测。在这些情况下，每一个信息都是有价值的。因此，重要的是要提取最大数量的信息功能。在这些考虑因素的推动下，我们引入了一种新的CNN体​​系结构，该体系结构可通过利用跳过连接以及连续的收缩和特征图的扩展来保留深，中间和浅层层的多尺度特征。使用来自胰腺导管腺癌（PDAC）CT扫描的非常低分辨率斑块的数据集，我们证明我们的网络可以超越最新模型的当前状态。